Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts.
نویسندگان
چکیده
The levels of lysine hydroxylase protein and the levels of the mRNAs for lysine hydroxylase and the alpha- and beta-subunits of proline 4-hydroxylase were measured in cultured human skin fibroblasts treated with 1 mM-minoxidil. The data demonstrate that minoxidil decreases the amount of lysine hydroxylase protein, this being due to a decrease in the level of lysine hydroxylase mRNA. The effect of minoxidil appears to be highly specific, as no changes were observed in the amounts of mRNAs for the alpha- and beta-subunits of proline 4-hydroxylase.
منابع مشابه
Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 283 ( Pt 1) شماره
صفحات -
تاریخ انتشار 1992